Expression, content, and localization of insulin-like growth factor I in human Achilles tendon
JL Olesen, KM Heinemeier, H Langberg… - Connective tissue …, 2006 - Taylor & Francis
In animals insulin-like growth factor I (IGF-I) stimulates collagen production by fibroblasts
and is expressed in tendons together with its binding protein 4 (IGFBP-4). However, the
presence of IGF-I and IGFBP-4 in human tendon tissue is not described. Tissue IGF-I content
was examined by immunoflourometric assay, real-time PCR, and immunohistochemistry
used to localize and determine expression of IGF-I and IGFBP-4 in 6 postmortem human
Achilles tendons. Tendon tissue concentrations of IGF-I were found to be 0.53±0.10 ng/g …
and is expressed in tendons together with its binding protein 4 (IGFBP-4). However, the
presence of IGF-I and IGFBP-4 in human tendon tissue is not described. Tissue IGF-I content
was examined by immunoflourometric assay, real-time PCR, and immunohistochemistry
used to localize and determine expression of IGF-I and IGFBP-4 in 6 postmortem human
Achilles tendons. Tendon tissue concentrations of IGF-I were found to be 0.53±0.10 ng/g …
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